Düşük Dozda N-Asetilsistein Uygulaması Diyabetik Yara İyileşmesini Hızlandırır mı?

The aim of this study to establish the effect systemic N-acetylcysteine (NAC) administration on oxidative–antioxidative balance, inflammatory markers, and collagen production during wound healing in diabetes. A total 24 male Wistar albino rats were randomly divided into 4 groups: control, streptozotocin-induced diabetic model, NAC treatment group, model with treatment. dorsal circular was created application (IP, 60 mg/kg) performed for 7 days groups. Lipid peroxidation, antioxidative parameters, NOx levels, amount tissue determined by spectrophotometric methods. Inflammatory markers detected ELISA. In tissues untreated rats, lipid peroxidation significantly increased. Superoxide dismutase catalase activities, glutathione reduced. Following administration, antioxidant status levels improved marker remarkably Additionally, model-NAC contraction Systemic accelerates diabetes reducing oxidative stress inflammation increasing production. As a consequence, therapy can be effective ameliorating